The value of gene Xpert MTB / RIF, ADA, TB-DNA in the early diagnosis of TB meningitis

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Diagnosis and treatment of TB patients with rifampicin resistance detected using Xpert(®) MTB/RIF in Zimbabwe.

SETTING In Zimbabwe, there are concerns about the management of tuberculosis (TB) patients with rifampicin (RMP) resistance diagnosed using Xpert(®) MTB/RIF. OBJECTIVE To assess linkages between diagnosis and treatment for these patients in Harare and Manicaland provinces in 2014. DESIGN A retrospective cohort study. RESULTS Of 20 329 Xpert assays conducted, 90% were successful, 11% detec...

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Rapid molecular TB diagnosis: evidence, policy making and global implementation of Xpert MTB/RIF.

If tuberculosis (TB) is to be eliminated as a global health problem in the foreseeable future, improved detection of patients, earlier diagnosis and timely identification of rifampicin resistance will be critical. New diagnostics released in recent years have improved this perspective but they require investments in laboratory infrastructure, biosafety and staff specialisation beyond the means ...

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Use of the Xpert MTB/RIF assay in the diagnosis of tuberculous meningitis: a cautionary note.

650 October 2014, Vol. 104, No. 10 Use of the Xpert MTB/RIF assay in the diagnosis of tuberculous meningitis: A cautionary note To the Editor: The Xpert MTB/RIF (Cepheid) assay is a nucleic acid amplification test developed to detect mycobacterial tuberc­ ulosis (MTB) infection and rifampicin resistance. It is a closed system, requires minimal training to use, and produces a result in a few hou...

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Diagnosing Xpert MTB/RIF negative TB: impact and cost of alternative algorithms for South Africa.

BACKGROUND Use of Xpert MTB/RIF is being scaled up throughout South Africa for improved diagnosis of tuberculosis (TB). A large proportion of HIV-infected patients with possible TB are Xpert-negative on their initial test, and the existing diagnostic algorithm calls for these patients to have sputum culture (Xpert followed by culture (X/C)). We modelled the costs and impact of an alternative di...

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Utility of the Xpert MTB/RIF Assay for Diagnosis of Tuberculous Meningitis

David Boulware discusses the challenges of diagnosing tuberculous meningitis and the implications of the study by Patel and colleagues using the Xpert MTB/RIF assay for diagnosis. Please see later in the article for the Editors' Summary.

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ژورنال

عنوان ژورنال: Cellular and Molecular Biology

سال: 2023

ISSN: ['1165-158X', '0145-5680']

DOI: https://doi.org/10.14715/cmb/2023.69.6.21